Somatic variation

(PI: Associate Professor Owen Siggs, Centre for Population Genomics)

Genetic variation is a key determinant of health, with thousands of inherited genetic variants associated with disease risk. But the inherited genome is not fixed, and we acquire vast numbers of somatic genetic variants as we age. With long-term funding from Snow Medical, we are studying the impact of somatic variants in diseases of inflammation and ageing using large population biobanks and unique patient cohorts, carefully phenotyped clinical samples, and gene-edited cells.

The Centre for Population Genomics is a national initiative, jointly housed at the Garvan Institute of Medical Research and the Murdoch Children’s Research Institute. We work all across the country and collaborate with partners internationally and in Australia.

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At CPG, we celebrate and respect diversity in our team and our work. We believe that including all human diversity in genomic research will empower medical care that benefits everyone.

We acknowledge the First Australian peoples on whose traditional lands we live and work across the country and pay our respects to their elders past, present and emerging. We gratefully accept the invitation in the Uluru Statement from the Heart “to walk with us in a movement of the Australian people for a better future”.